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While valid testosterone replacement therapy may promote weight loss in obese men, anabolic steroid misuse is not a recommended weight loss strategy. Testosterone replacement may reduce libido, decrease bone mass compared to placebo (32), increase fat mass (33), increase muscle mass (34), decrease muscle strength (35), and decrease lean body mass (36). Additionally, increasing muscle size can result in increased muscle mass gain. Thus, the potential adverse risks of testosterone supplementation are unknown. An important concern related to the use of testosterone replacement therapy is the impact on cardiovascular risk. As shown in , testosterone replacement therapy can reduce the rate of vascular events, but, this effect appears to be greater in men with high LDL cholesterol levels. We do not know the long-term impact of testosterone replacement therapy on cardiac outcomes. Treatment with testosterone may be of interest as a therapeutic agent to treat certain disorders associated with elevated LDL cholesterol or hyperlipidemia. Treatment with testosterone may be useful in lowering LDL cholesterol (37) and, more frequently, increasing plasma TG. However, the effects of testosterone replacement therapy on cardiovascular risk are unclear. Similar articles: